Mutagenicity and cytotoxicity of benz[a]anthracene diol epoxides and tetrahydro-epoxides: Exceptional activity of the bay region 1,2-epoxides
نویسندگان
چکیده
منابع مشابه
Mutagenicity of psoralen epoxides.
a Veterinary Toxicology and Entomology Research Laboratory, Agricultural Research, Science and Education Administration, U.S. Department o f Agriculture, College Station, TX 77840, b Western Regional Research Laboratory, Agricultural Research, Science and Education Administration, U.S. Department o f Agriculture, Berkeley, CA 94710, and c Department o f Entomology, University o f California, Ri...
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The mutagenicity of 17 aliphatic epoxides was determined using the specially constructed mutants of Salmonella typhimurium developed by Ames. The activity of these epoxides together with those reported in the literature as mutagens in strains TA100 and TA1535 depended on the degree of substitution around the oxirane ring. Monosubstituted oxiranes were the most potent mutagens in both strains. 1...
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Four benzo-ring epoxides of the environmental carcinogen benzo(a)pyrene (BP) were tested for mutagenic and cytotoxic activity in 3 strains of Salmonella typhimurium (TA1538, TA98, and TA100) and in Chinese hamster V79 cells. Although very unstable in aqueous solution, 7beta,8alpha-dihydroxy-0beta,10beta-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene (diol epoxide 1), with the 7-hydroxyl group on the s...
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The mutagenic activity of benzo(c)phenanthrene and some of its known and potential metabolites was evaluated in bac terial and mammalian cells either in the presence or absence of a metabolic activation system. trans-3,4-Dihydroxy-3,4-di hydrobenzo(c)phenanthrene [benzo(c)phenanthrene 3,4-di hydrodiol] was metabolized by a cytochrome P-450-dependent monooxygenase system to products which were s...
متن کاملExceptionally high tumor-initiating activity of benzo(c)phenanthrene bay-region diol-epoxides on mouse skin.
Benzo(c)phenanthrene [B(c)Ph], its three metabolically pos sible frans-dihydrodiols, and the diastereomeric bay-region diol-epoxides derived from frar>s-3,4-dihydroxy-3,4-dihydrobenzo(c)phenanthrene were tested for tumor-initiating activity on mouse skin. A single topical application of 0.4 or 2.0 /imol of compound was followed seven days later by twice-weekly applications of the tumor promotor...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1977
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.74.7.2746